Ubiquitin-related processes and innate immunity in C. elegans

Innate immunity is an evolutionary ancient defence strategy that serves to eliminate infectious agents while maintaining host health. It involves a complex network of sensors, signaling proteins and immune effectors detect the danger, then relay execute programme. Post-translational modifications relying on conserved ubiquitin ubiquitin-like are integral part system. Studies using invertebrate models infection, such as nematode Caenorhabditis elegans, have greatly contributed our understanding how ubiquitin-related processes act in sensing, regulate pathways, participate responses. This review highlights interest working with genetically tractable model organism illustrates C. elegans has been used identify ubiquitin-dependent mechanisms, discover novel ubiquitin-based resistance strategies mediate pathogen clearance, unravel role tolerance, preserving fitness during attack. Special emphasis placed mammals.